It installs on the thumb/index finger end of the grip as opposed to the throttle rocker on the heal end of the palm, so they don't interfere at all. And yes, it fits the 1" bar and has three different sizes for grips, so from what I understand it does fit the Kuryakyn ISO grips. I currently have the stock grips, but when I put the tbars on I will be putting the ISO grips on (along with ISO switchblade pegs and shifter cover, maybe highway pegs too...can't decide). As for operation of the very simple system, you roll back on the shifter, and then press down on the thumb tab to hold the grip in place. To release the grip, you just put your thumb under the tab and flip it up. While in the "locked" position, you can still manually turn the grip if needed for more or less throttle.