Stay on 1 leaving Calgary will take you thru Banff and Lake Louise, which should be the first big "wow" moment. Scenic isn't the word for it.
Stay on 1 until around Sicamous BC
I've taken this route hundreds of times with bike, car, tractor trailer and now my tow truck. I think I've pretty much wore out the highway. The only problem with taking this way is that although it's the TransCanada highway, once you get on the west side of Banff Nat'l Park where you're entering BC, it turns into 2 lane undivided and the traffic is unreal packed with motorhomes and transport trucks. There are quite a few passing lanes but you get in behind an RV going 80km/h (50mph) and you can expect to have a long day. Also, the BC government is in the process of SLOWLY twinning that stretch between the BC/AB border to almost Kamloops, where it stays divided all the way to Vancouver, so you can expect a lot of stopping for construction. I do have to say though that the construction crews are really good at shutting down the road and opening it for 15 minute intervals so the waits aren't that long but it does get annoying.
On the other hand, Jaymann is right. The scenery is definitely something to be experienced but like I said before, I've been down that way hundreds of times and have seen many improvements over the years and I can honestly say that I never get tired or bored of the same old. There are many places to pull off and rest, little towns and bigger towns to stop and eat and fuel up, little campgrounds to spend a night if you're into that or privately owned motels if you're not. If you choose to go this way, follow the TransCanada after Kamloops along the Fraser River. It's definitely the long way (by 2hrs) but it's definitely worth it. At the town of Cache Creek you have two options. You can continue along the TransCanada which brings you out at Hope or turn on Hwy 97 (Cariboo Hwy) and then onto Hwy 99 which brings you right in to North Vancouver. If you take 99, FILL UP at Cache Creek. Can't see anyone making it through with even 3/4 full.
If the traffic bothers you then maybe consider heading south from Calgary until you reach HWY 3(Crowsnest Hwy). Head west from there and the scenery is just as beautiful. If you go this way, I suggest that when you reach Creston you head north (Hwy 3A) to Kootenay Bay and catch the free ferry across. Again less traffic, more scenery. Follow the highway south to Nelson and carry on to connect back to Hwy 3 and follow that all the way to Hope and eventually into Vancouver.
Sorry for the rambling, I kinda get excited when I hear of a road trip and I feel the need to put my 50 bucks if I have it.
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